Israeli Company Moebius Medical Signs Deal With India’s Sun Pharma

Moebius Medical

Moebius Medical based in Israel has signed an exclusive global licensing deal with India’s Sun Pharmaceutical Industries Ltd.  The deal  involves the development of MM-II, a novel pharmaceutical candidate geared for the treatment of pain in osteoarthritis. According to Israel21C “MM-II is a non-opioid product that leverages the physical properties of proprietary liposomes to lubricate arthritic knee joints, to reduce friction and wear, and pain in the joints.”

Moebius Medical CEO Moshe Weinstein said, “The fact that our novel technology was conceived in Israel and developed within the RAD Biomed Accelerator, confirms the unique quality of the country’s biotechnology ecosystem. In fact, our technology was borne from the multidisciplinary cooperation between leading professors from three of Israel’s most prestigious research institutions: Prof. Yechezkel Barenholz of the Hebrew University, Prof. Izhak Etsion of the Technion Institute, and Prof. Dorit Nitzan of Hadassah Medical Center. I would especially like to thank Prof. Barenholz for his ongoing support of the company, together with Dr. Yaniv Dolev, whose vision and leadership in the company helped bring this partnership to fruition.”

MM-II is an intra-articular biolubricant injection.  The product is being developed to provide symptomatic relief of mild-to-moderate osteoarthritis pain. MM-II is based on patent-protected technology licensed by Moebius Medical from the Hebrew University of Jerusalem, Technion Israel Institute of Technology and Hadassah Medical Center.

Sun Pharma Global Head of Business Development Kirti Ganorkar said, “Our agreement with Moebius Medical for an osteoarthritis product is a part of our effort to build a branded product pipeline and enrich our global portfolio for pain products. We are encouraged to further develop MM-II and hope to bring a new innovative treatment to patients suffering from osteoarthritic pain.”

The agreement stipulates that Sun Pharma will fund further development of MM-II, and undertake its global commercialization. Moebius Medical has already completed a first-in-man clinical study at Hadassah Medical Center. The trial demonstrated the product’s quick action and potentially better results and relative safety for alleviating osteoarthritis pain as compared to Hyaluronic Acid injection.

Moebius Medical will conduct the requisite pre-clinical studies, and will be responsible for product development and manufacturing until the end of Phase-II studies. Mumbai based Sun Pharma will assume responsibility for further clinical studies, regulatory submissions and product commercialization.

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Israel’s Experience and Technologies Can Help Transform Agriculture in India

Originally Published in FirstPost in November.

Over the last 10 years, I have had the good fortune of meeting hundreds of small-scale farmers all over India. I came to appreciate their hard work, eagerness to progress, and the difficult physical and economic environment in which they work.

Farmers bitterly complain about these hardships, but they always light up when I mention that I am Israeli. Even in the remotest of villages, farmers are somehow well aware and appreciative of Israel’s agricultural achievements. Unfortunately, however, very few of those who adore Israel’s technologies also use them in their own farms. A tremendous potential therefore remains largely unfulfilled.

Indian agriculture has made incredible progress over the last few decades, but it needs to undergo a deep transformation. It must make more efficient use of scarce water resources, lest they deplete. It must make more efficient use of nitrogen fertilizers, lest they continue to pollute water and sicken children. It must make more judicious use of pesticides, lest they continue to poison farmers. And it must diversify.

Israel’s experience and its technologies can help, so the growing agricultural cooperation between the two countries is heartening. Several Indian states have opened Centres of Excellence with the Israeli government. Cooperation in the private sector is also growing.

Last week, an Israeli business and academic delegation, led by President Reuven Rivlin, was hosted by President Pranab Mukherjeein Agro Tech 2016 in Chandigarh. President Rivlin declared that “when Israeli companies and Indian farmers meet, they can mage magic happen”. In a seminar organised by the Confederation of Indian Industry and Tel Aviv University, called ‘Digital Pathways in Indian Agriculture’, Israeli and Indian scientists and businessmen introduced exciting new technologies with the potential to transform the Indian agricultural landscape.

As exciting as technological innovations are, making them impactful will require a broadening of perspective. Agronomists and plant scientists have made incredible progress in understanding what crops need in order to flourish. Now, we need to develop a similar understanding of what farmers need in order to flourish. Without such an understanding, even the most revolutionary technologies will likely remain unused by the hundreds of millions of smallholders who grow India’s food.

Take drip irrigation, the most famous Israeli agricultural technology. Drip irrigation is proven to deliver the dual benefit of increased production and reduced water, fertilizer and herbicide requirements, exactly what so many Indian farmers need. Why then does the market for drip irrigation, while growing, still represent only a small fraction of Indian farmers?

The answers to this and related questions have to do more with economics than with agronomy, and more with farmers than with the crops they grow. The problem is that finding business models and government policies that can spread improved technologies sustainably has simply turned out to be as difficult a puzzle as developing these technologies in the first place.

It is therefore not for lack of effort or resources that a country that has mastered nuclear and satellite technology is still struggling to replace antiquated farming practices or lift its farmers out of poverty. The challenge is much more complicated than it may seem. And I don’t mean to suggest no programmes are successful. For example, in some states, like Gujarat, drip irrigation has been spreading rapidly in recent years, likely thanks to effective administration of the national drip subsidy programme. But we know too little about what works and what doesn’t and why and when.

We need to direct the same kind of energies that we put into the “crop” aspect of the challenge into the “human” aspect of the challenge. Frankly, it doesn’t help that the majority of India’s brightest and most ambitious young direct their brainpower to the fields of engineering, medicine and information and communication technology, while so few choose to take on the challenge of sustainable rural development (of course, there are wonderful exceptions, but they are too few).

India can surely succeed in transforming its agriculture, and we in Israel are eager to help. Let us begin by recognising the importance of not just the “technical element”, but also the “human element”. Let us build a bi-national, long-term and systematic programme that brings together academia, the public sector and the private sector; engineers, agronomists, plant scientists, social scientists, policy specialists and entrepreneurs. Let us harness the amazing brainpower, entrepreneurship and creativity of our two countries’ young generations, and get them involved. And most importantly, let us not shy away from leaving our offices and our labs and our experimental farms and stepping into farmers’ own fields.

Academia can have a powerful role to play. My own institution, Tel Aviv University, is leading the way by forging alliances with leading Indian universities and working with the Confederation of Indian Industry (CII) to carve new paths forward. We can use these collaborations to create a prestigious programme for outstanding, brilliant young Israelis and Indians to work together in small inter-disciplinary teams, and develop and test, in fields and villages across India, new approaches and models for adapting and disseminating relevant technologies to farmers. Governments can provide support and then scale up and implement those approaches that prove to be effective.

I believe a programme of this kind can radically change the perception of agriculture by young Indians from a thing of the past to a science of the future, and attract bright, dedicated and idealistic students from both India and Israel. These students will forge personal ties that will strengthen our relationship as countries, and achieve something that only they, if anyone, can do: help make Indian agriculture a model for the other emerging economies who are facing similar challenges.

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Bibi Netanyahu: “This is Why People Are Coming to Israel”

Prime Minister Netanyahu spoke today at the Jerusalem Post Diplomatic Conference held in Jerusalem today.  He touched on the changing world and how Israel is leading in technology and innovation. He spoke about the changing relationships with the Arab world and the broader globe.

Watch the whole speech below:

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Healing Shattered Psyches on Scene of Traumatic Events

United Hatzalah of Israel inaugurates world’s first fully integrated emergency psychotrauma unit to complement EMTs in the field.

(Article Source: Israel21c.org)

Thirty Israeli EMTs, paramedics and doctors recently completed a training course qualifying them as psychotrauma volunteers and teachers for United Hatzalah, a private community-based network of voluntary first-responders across Israel.

The volunteers already started providing psychological first aid before the graduation ceremony on May 25, 2016. They responded to a bus bombing, three cases of sudden heart attack deaths and three incidents of crib death.

They will be on call whenever United Hatzalah is called to a scene of a terror attack, sudden death, child’s death, severe car accident, severe injuries, natural disaster, suicide and wartime trauma.

“The new psychotrauma unit is something that we have been working towards for a long time,” United Hatzalah Founder Eli Beer tells ISRAEL21c. He says the psychotrauma unit is the first in the world to be fully integrated within an emergency response organization.

“In order to assure that people are not only saved but have a normal life after the traumatic event that they experienced, we need to make sure that they receive not only medical treatment but psychological treatment.”

Beer relates that he and other medical responders “have often arrived at situations where people’s lives can be destroyed if they do not receive immediate psychological treatment. Our new psychotrauma unit is a project that can help provide care for all aspects of a traumatic event. The unit will enable United Hatzalah to help as many people as possible heal on a physical level as well as on an emotional and psychological level.”

First graduating class of United Hatzalah’s psychotrauma unit. Photo: courtesy
First graduating class of United Hatzalah’s psychotrauma unit. Photo: courtesy

Rickie Rabinowitz, one of the founders and instructors of the unit, said she considers psychotrauma as “another level of injury to treat beyond getting the wounded treated by the volunteer EMTs. The extra facet is coming to complement the work of the medic on the scene.”

The supervising psychiatrist of the unit, Dr. Gary Quinn, directs the EMDR Institute of Israel. EMDR (Eye Movement Desensitization and Reprocessing) is a form of psychotherapy aimed at forestalling development of trauma-related disorders caused by exposure to distressing, traumatizing or negative life events. Quinn specializes in crisis intervention and the treatment of anxiety, depressive disorders and post-traumatic stress disorder.

“Many first responders have been taught psychological first aid, which is an eight-stage method of helping people deal with a difficult event,” Quinn said. “This unit has received extensive training which primarily focuses on stage three of that process, which is the stabilization aspect. This step is the most difficult to deal with, and its difficulty is compounded when dealing with people who are in a highly activated state.”

Quinn added that to the best of his knowledge, “this is the first group of EMS responders who are being taught an extra level of stabilization. It is one of the first groups in the world that will be deployed with the specific purpose of providing psychological first aid, and we will need to do a lot of research as we go along.”

Job doesn’t end at the scene

The new unit is headed by Miriam Ballin, a marriage and family therapist as well as a volunteer medic for United Hatzalah.

“Stabilization can mean many different things,” Ballin explained. “We may need to stabilize the scene during an incident when the situation is so chaotic that no one can get their job done. Alternatively, we may be called upon to stabilize family members of the injured people who were hurt at the scene, or we may even be called upon to stabilize the patient in a case where the patient is so activated that the paramedics cannot treat the person.”

Jonathan Hoffman, one of the new graduates, said he is eager “to have a positive impact on people who are suffering from an immediate trauma. I want to be there for them, and in the moment provide them with care that can save their lives. That is what the psychotrauma unit is really all about.”

Ballin added that the job often does not end at the scene.

“Another job of ours is to ease the mourning process and help the person do the things that they will need to do in order to get through the chaotic period following a trauma — whether it is helping them make the first few phone calls for funeral arrangements or assisting them and providing support while empowering them enough so that they will be able to tell their children that a family member has passed away.

“The job is certainly not easy, but it is important for the person’s health and stability in the moment and hopefully in the future.”

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Israeli Innovations for the Disabled Get Google Grants

(Originally Published on Israel21c.org)

Technologies to improve accessibility include smartphone controlled by head movements, eye-controlled keyboard and Makeathon-in-a-box.

Two Israeli nonprofits are among 30 international winners of Impact Challenge grants from Google.org to promote technological innovations that will make the world more accessible for people with disabilities.

Beit Issie Shapiro in Ra’anana received two Impact Challenge grants.

It received $1,000,000 toward the joint development with Sesame Enable of a free solution that will allow people with limited mobility to operate smartphones with head movements. The beta product is now being distributed to individuals in Israel to test and gauge demand before a global rollout.

Beit Issie Shapiro also received $700,000 to develop Makeathon-in-a-box in conjunction with Tikkun Olam Makers (TOM), a project of the Tel Aviv-based Reut Group.

Makeathon-in-a-box is a template for community make-a-thons around the world that bring makers and people with disabilities together to build prototypes of new solutions for “orphan” accessibility challenges.

Prototypes that come from the make-a-thons will be open source, and featured solutions will be available for purchase on TOM’s website.

National health-support organization Ezer Mizion of Bnei Brak won a $400,000 grant from Google.org for its project with Israeli startup Click2speak to develop a keyboard controlled by eye tracking for people with limited mobility and high cognitive function.

In the United States alone, 7.5 million people have trouble using their voices, and many of them also have impaired motor skills, making effective communication a daily struggle. Click2Speak CTO Gal Sont knows this only too well, as he was diagnosed with ALS (amyotrophic lateral sclerosis) in 2009.

Using eye movements, Sont programmed a user-friendly, affordable and multilingual on-screen virtual keyboard controlled by eye tracking and an eye-operated communication system. The Ezer Mizion Augmentative and Alternative Communication Loan Center provides eligible clients with the beta version.

The Impact Challenge grant will allow Ezer Mizion and Click2Speak to pilot the product, gather user feedback and improve the core technology.